Resveratrol
Updated: 17 hours ago
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Resveratrol is one of those compounds like circumin that shows a great deal of promise as a cancer Adjuvant. Again the problem is that there is no money to be made from it. And we really need those studies to know how much is a therapeutic dose. The only side effects it seems to have is stomach aches and diarrhea in large doses. Maybe it's time for the government to put money into this kind of research and forget about the FDA making money on it.
Resveratrol, trans-3,5,4'-trihydroxystilbene, was first isolated in 1940 as a constituent of the roots of white hellebore (Veratrum grandiflorum O. Loes), but has since been found in various plants, including grapes, berries and peanuts. Besides cardioprotective effects, resveratrol exhibits anticancer properties, as suggested by its ability to suppress proliferation of a wide variety of tumor cells, including lymphoid and myeloid cancers; multiple myeloma; cancers of the breast, prostate, stomach, colon, pancreas, and thyroid; melanoma; head and neck squamous cell carcinoma; ovarian carcinoma;and cervical carcinoma.
In conclusion, the present study highlights a new cellular mechanism for the anti-breast cancer effects of RSVL (RESVERATROL): that is activation of the AC/PKA cascade. This pathway appears to disrupt necessary signaling mechanisms in breast cancer cells, thereby augmenting the cytotoxicity of RSVL. Such effects for RSVL were not mediated by interaction with ER, thus also indicating the versatility of the mechanisms entailing chemopreventive effects of RSVL. These studies may well substantiate the clinical utility of RSVL against breast cancer.
An easy to read article about Resveratrol
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